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Palladium-catalyzed annulation of arynes by o-halobenzamides: synthesis of phenanthridinones.

ABSTRACT: The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N-substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C-C and C-N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups.

SUBMITTER: Lu C

PROVIDER: S-EPMC3490708 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Palladium-catalyzed annulation of arynes by o-halobenzamides: synthesis of phenanthridinones.

Lu Chun C Dubrovskiy Anton V AV Larock Richard C RC

The Journal of organic chemistry 20120926 19

The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N-substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C-C and C-N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups. ...[more]

PMID: 23013049

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