Ontology highlight
ABSTRACT:
SUBMITTER: Apostolaki A
PROVIDER: S-EPMC3491690 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Apostolaki Angeliki A Harispe Laura L Calcagno-Pizarelli Ana María AM Vangelatos Ioannis I Sophianopoulou Vicky V Arst Herbert N HN Peñalva Miguel Angel MA Amillis Sotiris S Scazzocchio Claudio C
Molecular microbiology 20120411 3
Type I casein kinases are highly conserved among Eukaryotes. Of the two Aspergillus nidulans casein kinases I, CkiA is related to the δ/ε mammalian kinases and to Saccharomyces cerevisiae Hrr25p. CkiA is essential. Three recessive ckiA mutations leading to single residue substitutions, and downregulation using a repressible promoter, result in partial loss-of-function, which leads to a pleiotropic defect in amino acid utilization and resistance to toxic amino acid analogues. These phenotypes cor ...[more]