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Molecular dissection of the basal clades in the human Y chromosome phylogenetic tree.

ABSTRACT: One hundred and forty-six previously detected mutations were more precisely positioned in the human Y chromosome phylogeny by the analysis of 51 representative Y chromosome haplogroups and the use of 59 mutations from literature. Twenty-two new mutations were also described and incorporated in the revised phylogeny. This analysis made it possible to identify new haplogroups and to resolve a deep trifurcation within haplogroup B2. Our data provide a highly resolved branching in the African-specific portion of the Y tree and support the hypothesis of an origin in the north-western quadrant of the African continent for the human MSY diversity.

SUBMITTER: Scozzari R

PROVIDER: S-EPMC3492319 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Molecular dissection of the basal clades in the human Y chromosome phylogenetic tree.

Scozzari Rosaria R Massaia Andrea A D'Atanasio Eugenia E Myres Natalie M NM Perego Ugo A UA Trombetta Beniamino B Cruciani Fulvio F

PloS one 20121107 11

One hundred and forty-six previously detected mutations were more precisely positioned in the human Y chromosome phylogeny by the analysis of 51 representative Y chromosome haplogroups and the use of 59 mutations from literature. Twenty-two new mutations were also described and incorporated in the revised phylogeny. This analysis made it possible to identify new haplogroups and to resolve a deep trifurcation within haplogroup B2. Our data provide a highly resolved branching in the African-specif ...[more]

PMID: 23145109

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