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End-binding protein 1 controls signal propagation from the T cell receptor.


ABSTRACT: The role of microtubules (MTs) in the control and dynamics of the immune synapse (IS) remains unresolved. Here, we show that T cell activation requires the growth of MTs mediated by the plus-end specific protein end-binding 1 (EB1). A direct interaction of the T cell receptor (TCR) complex with EB1 provides the molecular basis for EB1 activity promoting TCR encounter with signalling vesicles at the IS. EB1 knockdown alters TCR dynamics at the IS and prevents propagation of the TCR activation signal to LAT, thus inhibiting activation of PLC?1 and its localization to the IS. These results identify a role for EB1 interaction with the TCR in controlling TCR sorting and its connection with the LAT/PLC?1 signalosome.

SUBMITTER: Martin-Cofreces NB 

PROVIDER: S-EPMC3492726 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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End-binding protein 1 controls signal propagation from the T cell receptor.

Martín-Cófreces Noa B NB   Baixauli Francesc F   López María J MJ   Gil Diana D   Monjas Alicia A   Alarcón Balbino B   Sánchez-Madrid Francisco F  

The EMBO journal 20120824 21


The role of microtubules (MTs) in the control and dynamics of the immune synapse (IS) remains unresolved. Here, we show that T cell activation requires the growth of MTs mediated by the plus-end specific protein end-binding 1 (EB1). A direct interaction of the T cell receptor (TCR) complex with EB1 provides the molecular basis for EB1 activity promoting TCR encounter with signalling vesicles at the IS. EB1 knockdown alters TCR dynamics at the IS and prevents propagation of the TCR activation sig  ...[more]

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