Ontology highlight
ABSTRACT:
SUBMITTER: Abdullah Z
PROVIDER: S-EPMC3492734 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20121012 21
Immunity against infection with Listeria monocytogenes is not achieved from innate immune stimulation by contact with killed but requires viable Listeria gaining access to the cytosol of infected cells. It has remained ill-defined how such immune sensing of live Listeria occurs. Here, we report that efficient cytosolic immune sensing requires access of nucleic acids derived from live Listeria to the cytoplasm of infected cells. We found that Listeria released nucleic acids and that such secreted ...[more]