Dataset Information

Metal-Assisted and Microwave-Accelerated Evaporative Crystallization: Application to L-Alanine.

ABSTRACT: L-Alanine is an important amino acid that plays a key role in the molecular structure of many proteins. Crystallized forms of this molecule are currently in high demand in chemical, pharmaceutics, and food industries. However, the traditional evaporative crystallization method takes up to several hours to complete and does not always consistently yield usable crystals. Using the metal-assisted and microwave-accelerated evaporative crystallization (MA-MAEC) technique, larger and better-organized L-alanine crystals were formed in a fraction of the time using room temperature crystallization. This technique may be applicable to organic molecules other than amino acids and thus will be able to produce the large amount of molecular crystals desired by industries today.

SUBMITTER: Alabanza AM

PROVIDER: S-EPMC3493173 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Metal-Assisted and Microwave-Accelerated Evaporative Crystallization: Application to L-Alanine.

Alabanza Anginelle M AM Aslan Kadir K

Crystal growth & design 20110830 10

L-Alanine is an important amino acid that plays a key role in the molecular structure of many proteins. Crystallized forms of this molecule are currently in high demand in chemical, pharmaceutics, and food industries. However, the traditional evaporative crystallization method takes up to several hours to complete and does not always consistently yield usable crystals. Using the metal-assisted and microwave-accelerated evaporative crystallization (MA-MAEC) technique, larger and better-organized ...[more]

PMID: 23144593

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Project description:In this paper, we tested a hypothesis that the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique, based on the combined use of low-power medical microwave heating (MWH) and gold nanoparticles (Au NPs), can be used to decrystallize laboratory-prepared monosodium urate monohydrate crystal aggregate (pseudo-tophus) placed in three-dimensional (3D) synthetic human joint models. To simulate a potential treatment of chronic tophaceous gout using the MAMAD technique, we used three different 3D synthetic human joint models and assessed the percent mass reduction (PMR, i.e., decrystallization) of pseudo-tophus and microwave-induced synthetic skin patch damage after MAMAD sessions (a MAMAD session = 120 s of MWH in the presence of Au NPs). Our three synthetic joint models are: Model 1: Application of seven MAMAD sessions in a closed synthetic joint with a pseudo-bursa containing a pseudo-tophus submerged in a solution of 20 nm Au NPs followed by dehydration of pseudo-tophus after each MAMAD session to assess PMR. Model 2: Application of seven MAMAD sessions in a closed or open synthetic joint with a pseudo-bursa containing a pseudo-tophus submerged in a solution of Au NPs followed by intermittent dehydration of pseudo-tophus after seven MAMAD sessions to assess PMR. Model 3: Application of 18 MAMAD sessions in a rotated closed synthetic joint (three sides are heated separately) with a pseudo-bursa containing a pseudo-tophus submerged in a solution of Au NPs followed by dehydration after every three MAMAD sessions to assess PMR. After a single MAMAD session, pseudo-tophus exposed to MWH and Au NPs had an average PMR of 8.30% (up to an overall PMR of 15%), and microwave-induced damage to the synthetic skin can be controlled by the use of a sacrificial skin sample and by adjusting the duration and the number of the MAMAD sessions. Computational electromagnetic simulations predict a 10% absorption of electric field by the pseudo-tophus placed in the synthetic joint models, which led us to conclude that a medical microwave source with higher power than 20 W can potentially be used with the MAMAD technique.

Dataset Information

Metal-Assisted and Microwave-Accelerated Evaporative Crystallization: Application to L-Alanine.

Publications

Metal-Assisted and Microwave-Accelerated Evaporative Crystallization: Application to L-Alanine.

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