Ontology highlight
ABSTRACT:
SUBMITTER: Perkins MR
PROVIDER: S-EPMC3493478 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Perkins Molly R MR Ryschkewitsch Caroline C Liebner Julia C JC Monaco Maria Chiara G MC Himelfarb Danielle D Ireland Sara S Roque Annelys A Edward Heather L HL Jensen Peter N PN Remington Gina G Abraham Thomas T Abraham Jaspreet J Greenberg Benjamin B Kaufman Charles C LaGanke Chris C Monson Nancy L NL Xu Xiaoning X Frohman Elliot E Major Eugene O EO Douek Daniel C DC
PLoS pathogens 20121108 11
Progressive multifocal leukoencephalopathy (PML) induced by JC virus (JCV) is a risk for natalizumab-treated multiple sclerosis (MS) patients. Here we characterize the JCV-specific T cell responses in healthy donors and natalizumab-treated MS patients to reveal functional differences that may account for the development of natalizumab-associated PML. CD4 and CD8 T cell responses specific for all JCV proteins were readily identified in MS patients and healthy volunteers. The magnitude and quality ...[more]