Ontology highlight
ABSTRACT:
SUBMITTER: Dhatwalia R
PROVIDER: S-EPMC3493617 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Dhatwalia Richa R Singh Harkewal H Solano Luis M LM Oppenheimer Michelle M Robinson Reeder M RM Ellerbrock Jacob F JF Sobrado Pablo P Tanner John J JJ
Journal of the American Chemical Society 20121019 43
UDP-galactopyranose mutase (UGM) plays an essential role in galactofuranose biosynthesis in microorganisms by catalyzing the conversion of UDP-galactopyranose to UDP-galactofuranose. The enzyme has gained attention recently as a promising target for the design of new antifungal, antitrypanosomal, and antileishmanial agents. Here we report the first crystal structure of UGM complexed with its redox partner NAD(P)H. Kinetic protein crystallography was used to obtain structures of oxidized Aspergil ...[more]