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A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.


ABSTRACT: Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. Here we present the results of a multi-omic analysis of Rhodosporidium toruloides, a robust triacylglycerol-producing fungus. The assembly of genome and transcriptome sequencing data reveals a genome of 20.2 Mb containing 8,171 protein-coding genes, the majority of which have multiple introns. Genes including a novel fatty acid synthase are predicted to participate in metabolic pathways absent in non-oleaginous yeasts. Transcriptomic and proteomic data suggest that lipid accumulation under nitrogen-limited conditions correlates with the induction of lipogenesis, nitrogenous compound recycling, macromolecule metabolism and autophagy. The multi-omic map of R. toruloides therefore provides a valuable resource for efforts to rationally engineer lipid-production pathways.

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC3493640 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.

Zhu Zhiwei Z   Zhang Sufang S   Liu Hongwei H   Shen Hongwei H   Lin Xinping X   Yang Fan F   Zhou Yongjin J YJ   Jin Guojie G   Ye Mingliang M   Zou Hanfa H   Zhao Zongbao K ZK  

Nature communications 20120101


Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. Here we present the results of a multi-omic analysis of Rhodosporidium toruloides, a robust triacylglycerol-producing fungus. The assemb  ...[more]

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