Ontology highlight
ABSTRACT:
SUBMITTER: Watt NT
PROVIDER: S-EPMC3493655 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Watt Nicole T NT Taylor David R DR Kerrigan Talitha L TL Griffiths Heledd H HH Rushworth Jo V JV Rushworth Jo V JV Whitehouse Isobel J IJ Hooper Nigel M NM
Nature communications 20120101
Zinc is released into the synaptic cleft upon exocytotic stimuli, although the mechanism for its reuptake into neurons is unresolved. Here we show that the cellular prion protein enhances the uptake of zinc into neuronal cells. This prion-protein-mediated zinc influx requires the octapeptide repeats and amino-terminal polybasic region in the prion protein, but not its endocytosis. Selective antagonists of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors block the prion protein-m ...[more]