Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression.
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ABSTRACT:
SUBMITTER: Galban CJ
PROVIDER: S-EPMC3493851 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression.
Galbán Craig J CJ Han Meilan K MK Boes Jennifer L JL Chughtai Komal A KA Meyer Charles R CR Johnson Timothy D TD Galbán Stefanie S Rehemtulla Alnawaz A Kazerooni Ella A EA Martinez Fernando J FJ Ross Brian D BD
Nature medicine 20121007 11
Chronic obstructive pulmonary disease (COPD) is increasingly being recognized as a highly heterogeneous disorder, composed of varying pathobiology. Accurate detection of COPD subtypes by image biomarkers is urgently needed to enable individualized treatment, thus improving patient outcome. We adapted the parametric response map (PRM), a voxel-wise image analysis technique, for assessing COPD phenotype. We analyzed whole-lung computed tomography (CT) scans acquired at inspiration and expiration o ...[more]
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