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Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology.


ABSTRACT: The small conducting airways are the major site of obstruction in chronic obstructive pulmonary disease (COPD). This study examined small airway pathology using a novel combination of multidetector row computed tomography (MDCT), micro-computed tomography (microCT) and histology.Airway branches visible on specimen MDCT were counted and the dimensions of the third- to fifth-generation airways were computed, while the terminal bronchioles (designated TB), preterminal bronchioles (TB-1) and pre-preterminal bronchioles (TB-2) were examined with microCT and histology in eight explanted lungs with end-stage COPD and seven unused donor lungs that served as controls.On MDCT, COPD lungs showed a decrease in the number of 2-2.5?mm diameter airways and the lumen area of fifth-generation airways, while on microCT there was a reduction in the number of terminal bronchioles as well as a decrease in the luminal areas, wall volumes and alveolar attachments to the walls of TB, TB-1 and TB-2 bronchioles. The combination of microCT and histology showed increased B-cell infiltration into the walls of TB-1 and TB-2 bronchioles, and this change was correlated with a reduced number of alveolar attachments in COPD.Small airways disease extends from 2?mm diameter airways to the terminal bronchioles in COPD. Destruction of alveolar attachments may be driven by a B-cell-mediated immune response in the preterminal bronchioles.

SUBMITTER: Tanabe N 

PROVIDER: S-EPMC6691959 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology.

Tanabe Naoya N   Vasilescu Dragoş M DM   Kirby Miranda M   Coxson Harvey O HO   Verleden Stijn E SE   Vanaudenaerde Bart M BM   Kinose Daisuke D   Nakano Yasutaka Y   Paré Peter D PD   Hogg James C JC  

The European respiratory journal 20180214 2


The small conducting airways are the major site of obstruction in chronic obstructive pulmonary disease (COPD). This study examined small airway pathology using a novel combination of multidetector row computed tomography (MDCT), micro-computed tomography (microCT) and histology.Airway branches visible on specimen MDCT were counted and the dimensions of the third- to fifth-generation airways were computed, while the terminal bronchioles (designated TB), preterminal bronchioles (TB-1) and pre-pre  ...[more]

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