Ontology highlight
ABSTRACT:
SUBMITTER: Davies BS
PROVIDER: S-EPMC3494248 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Davies Brandon S J BS Goulbourne Chris N CN Barnes Richard H RH Turlo Kirsten A KA Gin Peter P Vaughan Sue S Vaux David J DJ Bensadoun André A Beigneux Anne P AP Fong Loren G LG Young Stephen G SG
Journal of lipid research 20120924 12
Lipoprotein lipase (LPL) is secreted into the interstitial spaces by adipocytes and myocytes but then must be transported to the capillary lumen by GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. The mechanism by which GPIHBP1 and LPL move across endothelial cells remains unclear. We asked whether the transport of GPIHBP1 and LPL across endothelial cells was uni- or bidirectional. We also asked whether GPIHBP1 and LPL are transported across cells in vesic ...[more]