Ontology highlight
ABSTRACT:
SUBMITTER: Young SG
PROVIDER: S-EPMC3196223 | biostudies-other | 2011 Nov
REPOSITORIES: biostudies-other
Young Stephen G SG Davies Brandon S J BS Voss Constance V CV Gin Peter P Weinstein Michael M MM Tontonoz Peter P Reue Karen K Bensadoun André A Fong Loren G LG Beigneux Anne P AP
Journal of lipid research 20110815 11
Interest in lipolysis and the metabolism of triglyceride-rich lipoproteins was recently reignited by the discovery of severe hypertriglyceridemia (chylomicronemia) in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1)-deficient mice. GPIHBP1 is expressed exclusively in capillary endothelial cells and binds lipoprotein lipase (LPL) avidly. These findings prompted speculation that GPIHBP1 serves as a binding site for LPL in the capillary lumen, creating "a p ...[more]