Ontology highlight
ABSTRACT:
SUBMITTER: Dumelin CE
PROVIDER: S-EPMC3494293 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Dumelin Christoph E CE Chen Yiyun Y Leconte Aaron M AM Chen Y Grace YG Liu David R DR
Nature chemical biology 20120916 11
A general MS-based screen for unusually hydrophobic cellular small molecule-RNA conjugates revealed geranylated RNA in Escherichia coli, Enterobacter aerogenes, Pseudomonas aeruginosa and Salmonella enterica var. Typhimurium. The geranyl group is conjugated to the sulfur atom in two 5-methylaminomethyl-2-thiouridine nucleotides. These geranylated nucleotides occur in the first anticodon position of tRNA(Glu)(UUC), tRNA(Lys)(UUU) and tRNA(Gln)(UUG) at a frequency of up to 6.7% (~400 geranylated n ...[more]