Ontology highlight
ABSTRACT:
SUBMITTER: Bienes-Martinez R
PROVIDER: S-EPMC3494377 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Bienes-Martínez Raquel R Ordóñez Angel A Feijoo-Cuaresma Mónica M Corral-Escariz María M Mateo Gloria G Stenina Olga O Jiménez Benilde B Calzada María J MJ
Scientific reports 20121109
Thrombospondin-1 is a matricellular protein with potent antitumour activities, the levels of which determine the fate of many different tumours, including renal carcinomas. However, the factors that regulate this protein remain unclear. In renal carcinomas, hypoxic conditions enhance the expression of angiogenic factors that help adapt tumour cells to their hostile environment. Therefore, we hypothesized that anti-angiogenic factors should correspondingly be dampened. Indeed, we found that hypox ...[more]