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Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma.


ABSTRACT: BACKGROUND: Melanoma antigen D1 (MAGED1) is a member of the type II melanoma antigen (MAGE) family. The down-regulation of MAGED1 expression has been shown in breast carcinoma cell lines and in glioma stem cells and may play an important role in apoptosis and anti-tumorigenesis. However, there is no report on its clinical role in colorectal cancer (CRC). METHODS: We examined the expression of MAGED1 by qPCR in colorectal cancer tissues and their adjacent non-tumorous tissues taken from 6 cases and performed Western blotting and IHC analyses. In addition, we analyzed MAGED1 expression in 285 clinicopathologically characterized colorectal cancer patients. RESULTS: MAGED1 expression was significantly down-regulated in colorectal cancer tissues compared with adjacent non-tumorous tissues and was associated with clinical stage (p?

SUBMITTER: Zeng ZL 

PROVIDER: S-EPMC3494540 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma.

Zeng Zhao-lei ZL   Wu Wen-jing WJ   Yang Jing J   Tang Zhen-jie ZJ   Chen Dong-liang DL   Qiu Miao-zhen MZ   Luo Hui-yan HY   Wang Zhi-qiang ZQ   Jin Ying Y   Wang De-shen DS   Xu Rui-hua RH  

Journal of translational medicine 20120831


<h4>Background</h4>Melanoma antigen D1 (MAGED1) is a member of the type II melanoma antigen (MAGE) family. The down-regulation of MAGED1 expression has been shown in breast carcinoma cell lines and in glioma stem cells and may play an important role in apoptosis and anti-tumorigenesis. However, there is no report on its clinical role in colorectal cancer (CRC).<h4>Methods</h4>We examined the expression of MAGED1 by qPCR in colorectal cancer tissues and their adjacent non-tumorous tissues taken f  ...[more]

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