Prognostic relevance of topoisomerase II ? and minichromosome maintenance protein 6 expression in colorectal cancer.

ABSTRACT:

Background

Despite rising incidence rates of colorectal malignancies, only a few prognostic tools have been implemented in proven clinical routine. Cell division and proliferation play a significant role in malignancies. In terms of colorectal cancer, the impact of proliferation associated proteins is controversially debated. The aim of our study was to examine the expression of topoisomerase II ? and minichromosome maintenance protein 6 and to correlate these findings with the clinical data.

Methods

Tissue samples of 619 patients in total were stained using the antibodies Ki-S4 and Ki-MCM6 targeting topoisomerase II ? as well as minichromosome maintenance protein 6. The median rate of proliferation was correlated with clinical and follow up data.

Results

The expression rate of minichromosome maintenance protein 6 is significantly higher than the proportion of topoisomerase II ? in tumour cells (p?ConclusionsWe have demonstrated that high expression rates of proliferative markers is linked to a beneficial patient outcome. According to the general opinion, a high expression rate correlates with a poor patient outcome. In this study, we were able to refute this assertion.

SUBMITTER: Hendricks A 

PROVIDER: S-EPMC6507179 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature