Combinatorial Immunotherapy: PD-1 may not be LAG-ing behind any more.
Ontology highlight
ABSTRACT:
SUBMITTER: Turnis ME
PROVIDER: S-EPMC3494635 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Combinatorial Immunotherapy: PD-1 may not be LAG-ing behind any more.
Turnis Meghan E ME Korman Alan J AJ Drake Charles G CG Vignali Dario A A DA
Oncoimmunology 20121001 7
Cancer immunotherapy attempts to harness the immune system by breaking tolerance and generating a robust anticancer response. We have recently demonstrated a synergistic enhancement in tumor clearance following therapeutic, dual PD-1 and LAG-3 blockade. Here, we discuss the implications of these findings in the context of future combinatorial immunotherapeutic approaches. ...[more]
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