Efficient, divergent synthesis of cryptophycin unit A analogues.
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ABSTRACT: A flexible and divergent synthesis of cryptophycin unit A analogues is described. This method relies on iridium-catalysed stereo- and enantioselective crotylation and chemoselective one-pot oxidative olefination to access common intermediate . Heck, cross metathesis, and Suzuki-Miyaura reactions are illustrated for the generation of methyl ester unit A analogues .
SUBMITTER: Bolduc KL
PROVIDER: S-EPMC3494784 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
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