Ontology highlight
ABSTRACT:
SUBMITTER: Reznichenko A
PROVIDER: S-EPMC3495046 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Reznichenko Anna A Böger Carsten A CA Snieder Harold H van den Born Jacob J de Borst Martin H MH Damman Jeffrey J van Dijk Marcory C R F MC van Goor Harry H Hepkema Bouke G BG Hillebrands Jan-Luuk JL Leuvenink Henri G D HG Niesing Jan J Bakker Stephan J L SJ Seelen Marc M Navis Gerjan G
BMC medical genetics 20120905
<h4>Background</h4>In recent genetic association studies, common variants including rs12917707 in the UMOD locus have shown strong evidence of association with eGFR, prevalent and incident chronic kidney disease and uromodulin urinary concentration in general population cohorts. The association of rs12917707 with end-stage renal disease (ESRD) in a recent case-control study was only nominally significant.<h4>Methods</h4>To investigate whether rs12917707 associates with ESRD, graft failure (GF) a ...[more]