Dataset Information

Apolipoprotein E gene variants on the risk of end stage renal disease.

ABSTRACT:

Objective

End-stage renal disease (ESRD) is a severe health concern over the world. Associations between apolipoprotein E (apoE) gene polymorphisms and the risk of ESRD remained inconclusive. This study aimed to investigate the association between apoE gene polymorphisms and ESRD susceptibility.

Methods

Databases including PubMed, Embase, Web of Science and the Cochrane Library were searched to find relevant studies. Meta-analysis method was used synthesize the eligible studies.

Results

Sixteen pertinent case-control studies which included 3510 cases and 13924 controls were analyzed. A signi?cant association was found between ?2 allele and the ESRD risk (odds ratio (OR) = 1.30, 95% con?dence interval (CI) 1.15-1.46, P < 0.0001; I (2) = 18%, P for heterogeneity = 0.24). The ?2?3, ?2?4, ?3?3, ?3?4, ?4?4, ?3 and ?4 were not associated with the susceptibility of ESRD. In the subgroup analysis by ethnicity, there was a statistically significant association between ?2?3 or ?2 allele and ESRD risk in East Asians (OR = 1.66, 95% CI 1.31-2.10, P < 0.0001; OR = 1.62, 95% CI 1.31-2.01, P < 0.0001, respectively), but not in Caucasians. E2 carriers had higher plasma apoE (mean difference = 16.24 mg/L, 95% CI 7.76-24.73, P = 0.0002) than the (?3 + ?4) carriers in patients with ESRD. The publication bias was not significant.

Conclusion

The ?2 allele of apoE gene might increase the risk of ESRD. E2 carriers expressed higher level of plasma apoE in patients with ESRD. More well-designed studies are needed to con?rm these associations in the future.

SUBMITTER: Xue C

PROVIDER: S-EPMC3862680 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Apolipoprotein E gene variants on the risk of end stage renal disease.

Xue Cheng C Nie Wei W Tang Dan D Yi Lujiang L Mei Changlin C

PloS one 20131213 12

<h4>Objective</h4>End-stage renal disease (ESRD) is a severe health concern over the world. Associations between apolipoprotein E (apoE) gene polymorphisms and the risk of ESRD remained inconclusive. This study aimed to investigate the association between apoE gene polymorphisms and ESRD susceptibility.<h4>Methods</h4>Databases including PubMed, Embase, Web of Science and the Cochrane Library were searched to find relevant studies. Meta-analysis method was used synthesize the eligible studies.<h ...[more]

PMID: 24349494

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Dataset Information

Apolipoprotein E gene variants on the risk of end stage renal disease.

Objective

Methods

Results

Conclusion

Publications

Apolipoprotein E gene variants on the risk of end stage renal disease.

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