Ontology highlight
ABSTRACT:
SUBMITTER: Rashidian M
PROVIDER: S-EPMC3495172 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Rashidian Mohammad M Dozier Jonathan K JK Lenevich Stepan S Distefano Mark D MD
Chemical communications (Cambridge, England) 20101022 47
An aldehyde-containing alternative substrate for protein farnesyltransferase was prepared and shown to be enzymatically incorporated into a peptide and a protein. The protein was subsequently immobilized onto aminooxy-functionalized agarose beads or labeled with a fluorophore. This method for protein modification provides an alternative to the commonly employed Cu(I)-catalyzed click reaction. ...[more]