Ontology highlight
ABSTRACT:
SUBMITTER: Agten SM
PROVIDER: S-EPMC5132021 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Agten Stijn M SM Koenen Rory R RR Ippel Hans H Eckardt Veit V von Hundelshausen Philipp P Mayo Kevin H KH Weber Christian C Hackeng Tilman M TM
Angewandte Chemie (International ed. in English) 20161027 48
Protein-protein interactions (PPIs) govern most processes in living cells. Current drug development strategies are aimed at disrupting or stabilizing PPIs, which require a thorough understanding of PPI mechanisms. Examples of such PPIs are heteromeric chemokine interactions that are potentially involved in pathological disorders such as cancer, atherosclerosis, and HIV. It remains unclear whether this functional modulation is mediated by heterodimer formation or by the additive effects of mixed ...[more]