Ontology highlight
ABSTRACT:
SUBMITTER: Trost BM
PROVIDER: S-EPMC3495600 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20121010 42
We describe a palladium-catalyzed diastereo- and enantioselective formal [3 + 2]-cycloaddition between substituted vinylcyclopropanes and electron-deficient olefins in the form of azlactone- and Meldrum's acid alkylidenes to give highly substituted cyclopentane products. By modulation of the electronic properties of the vinylcyclopropane and the electron-deficient olefin, high levels of stereoselectivity were obtained. The remote stereoinduction afforded by the catalyst, distal from the chiral p ...[more]