Neural progenitor cells regulate microglia functions and activity.
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ABSTRACT:
SUBMITTER: Mosher KI
PROVIDER: S-EPMC3495979 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Publications
Neural progenitor cells regulate microglia functions and activity.
Mosher Kira I KI Andres Robert H RH Fukuhara Takeshi T Bieri Gregor G Hasegawa-Moriyama Maiko M He Yingbo Y Guzman Raphael R Wyss-Coray Tony T
Nature neuroscience 20121021 11
We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity. ...[more]
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