Ontology highlight
ABSTRACT:
SUBMITTER: Mitkevich VA
PROVIDER: S-EPMC3496166 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Mitkevich Vladimir A VA Shyp Viktoriya V Petrushanko Irina Yu IY Soosaar Aksel A Atkinson Gemma C GC Tenson Tanel T Makarov Alexander A AA Hauryliuk Vasili V
Scientific reports 20121113
Translational GTPases (trGTPases) are involved in all four stages of protein biosynthesis: initiation, elongation, termination and ribosome recycling. The trGTPases Initiation Factor 2 (IF2) and Elongation Factor G (EF-G) respectively orchestrate initiation complex formation and translocation of the peptidyl-tRNA:mRNA complex through the bacterial ribosome. The ribosome regulates the GTPase cycle and efficiently discriminates between the GDP- and GTP-bound forms of these proteins. Using Isotherm ...[more]