Ontology highlight
ABSTRACT:
SUBMITTER: Sando R
PROVIDER: S-EPMC3496186 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Sando Richard R Gounko Natalia N Pieraut Simon S Liao Lujian L Yates John J Maximov Anton A
Cell 20121101 4
Neuronal activity influences genes involved in circuit development and information processing. However, the molecular basis of this process remains poorly understood. We found that HDAC4, a histone deacetylase that shuttles between the nucleus and cytoplasm, controls a transcriptional program essential for synaptic plasticity and memory. The nuclear import of HDAC4 and its association with chromatin is negatively regulated by NMDA receptors. In the nucleus, HDAC4 represses genes encoding constit ...[more]