Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC7826339 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Zhou Zhiwen Z Okamoto Kazuki K Onodera Junya J Hiragi Toshimitsu T Andoh Megumi M Ikawa Masahito M Tanaka Kenji F KF Ikegaya Yuji Y Koyama Ryuta R
Proceedings of the National Academy of Sciences of the United States of America 20210101 3
Astrocytes play a key role in brain homeostasis and functions such as memory. Specifically, astrocytes express multiple receptors that transduce signals via the second messenger cAMP. However, the involvement of astrocytic cAMP in animal behavior and the underlying glial-neuronal interactions remains largely unknown. Here, we show that an increase in astrocytic cAMP is sufficient to induce synaptic plasticity and modulate memory. We developed a method to increase astrocytic cAMP levels in vivo u ...[more]