A magnetic Gram stain for bacterial detection.
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ABSTRACT:
SUBMITTER: Budin G
PROVIDER: S-EPMC3496380 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
A magnetic Gram stain for bacterial detection.
Budin Ghyslain G Chung Hyun Jung HJ Lee Hakho H Weissleder Ralph R
Angewandte Chemie (International ed. in English) 20120628 31
Magnetizing: Bacteria are often classified into gram-positive and gram-negative strains by staining with crystal violet (CV). The described bioorthogonal modification of CV with trans-cyclooctene (TCO) can be used to render gram-positive bacteria magnetic with tetrazine-functionalized magnetic nanoparticles (MNP-Tz). This method allows class-specific automated magnetic detection and magnetic separation. ...[more]
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