Ontology highlight
ABSTRACT:
SUBMITTER: Lin FT
PROVIDER: S-EPMC3496872 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Lin Fang-Tsyr FT Lai Yun-Ju YJ Makarova Natalia N Tigyi Gabor G Lin Weei-Chin WC
The Journal of biological chemistry 20071026 52
Lysophosphatidic acid (LPA) promotes cell survival through the activation of G protein-coupled LPA receptors. However, whether different LPA receptors activate distinct anti-apoptotic signaling pathways is not yet clear. Here we report a novel mechanism by which the LPA(2) receptor targets the proapoptotic Siva-1 protein for LPA-dependent degradation, thereby attenuating Siva-1 function in DNA damage response. The carboxyl-terminal tail of the LPA(2) receptor, but not LPA(1) or LPA(3) receptor, ...[more]