Ontology highlight
ABSTRACT:
SUBMITTER: Hu J
PROVIDER: S-EPMC4128188 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Hu Jiancheng J Oda Shannon K SK Shotts Kristin K Donovan Erin E EE Strauch Pamela P Pujanauski Lindsey M LM Victorino Francisco F Al-Shami Amin A Fujiwara Yuko Y Tigyi Gabor G Oravecz Tamas T Pelanda Roberta R Torres Raul M RM
Journal of immunology (Baltimore, Md. : 1950) 20140602 1
Lysophospholipids have emerged as biologically important chemoattractants capable of directing lymphocyte development, trafficking, and localization. Lysophosphatidic acid (LPA) is a major lysophospholipid found systemically, and its levels are elevated in certain pathological settings, such as cancer and infections. In this study, we demonstrate that BCR signal transduction by mature murine B cells is inhibited upon LPA engagement of the LPA5 (GPR92) receptor via a Gα12/13-Arhgef1 pathway. The ...[more]