Ontology highlight
ABSTRACT:
SUBMITTER: Samba-Louaka A
PROVIDER: S-EPMC3497413 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Samba-Louaka Ascel A Stavru Fabrizia F Cossart Pascale P
Infection and immunity 20120924 12
Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the human telomerase complex. Growing evidence suggests that hTERT also contributes to the cell physiology independently of telomere elongation. However, its role in bacterial infection is unknown. Here we show that hTERT is critical for Listeria monocytogenes infection, as the depletion of hTERT impaired bacterial intracellular replication. In addition, we observed that L. monocytogenes caused a decrease in hTERT levels ...[more]