Ontology highlight
ABSTRACT:
SUBMITTER: Warren CA
PROVIDER: S-EPMC3497433 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Warren Cirle A CA Li Yuesheng Y Calabrese Gina M GM Freire Rosemayre S RS Zaja-Milatovic Snjezana S van Opstal Edward E Figler Robert A RA Linden Joel J Guerrant Richard L RL
Infection and immunity 20121008 12
Clostridium difficile toxins A (TcdA) and B (TcdB) induce a pronounced systemic and intestinal inflammatory response. A(2B) adenosine receptors (A(2B)ARs) are the predominant adenosine receptors in the intestinal epithelium. We investigated whether A(2B)ARs are upregulated in human intestinal cells by TcdA or TcdB and whether blockade of A(2B)ARs can ameliorate C. difficile TcdA-induced enteritis and alter the outcome of C. difficile infection (CDI). Adenosine receptor subtype (A(1), A(2A), A(2B ...[more]