Ontology highlight
ABSTRACT:
SUBMITTER: Alysandratos KD
PROVIDER: S-EPMC3498358 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Alysandratos Konstantinos-Dionysios KD Asadi Shahrzad S Angelidou Asimenia A Zhang Bodi B Sismanopoulos Nikolaos N Yang Hailing H Critchfield Agatha A Theoharides Theoharis C TC
PloS one 20121114 11
Stress affects immunity, but the mechanism is not known. Neurotensin (NT) and corticotropin-releasing hormone (CRH) are secreted under stress in various tissues, and have immunomodulatory actions. We had previously shown that NT augments the ability of CRH to increase mast cell-dependent skin vascular permeability in rodents. Here we show that NT triggered human mast cell degranulation and significantly augmented CRH-induced vascular endothelial growth factor (VEGF) release. Investigation of var ...[more]