Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis.

ABSTRACT: GilOII has been unambiguously identified as the key enzyme performing the crucial C-C bond cleavage reaction responsible for the unique rearrangement of a benz[a]anthracene skeleton to the benzo[d]naphthopyranone backbone typical of the gilvocarcin-type natural anticancer antibiotics. Further investigations of this enzyme led to the isolation of a hydroxyoxepinone intermediate, leading to important conclusions regarding the cleavage mechanism.

SUBMITTER: Tibrewal N 

PROVIDER: S-EPMC3498853 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature