Ontology highlight
ABSTRACT:
SUBMITTER: Rauch J
PROVIDER: S-EPMC3499776 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Rauch Jens J Kolch Walter W Mahmoudi Morteza M
Scientific reports 20121116
The interaction of nanoparticles (NPs) with living organisms has become a focus of public and scientific debate due to their potential wide applications in biomedicine, but also because of unwanted side effects. Here, we show that superparamagnetic iron oxide NPs (SPIONs) with different surface coatings can differentially affect signal transduction pathways. Using isogenic pairs of breast and colon derived cell lines we found that the stimulation of ERK and AKT signaling pathways by SPIONs is se ...[more]