Ontology highlight
ABSTRACT:
SUBMITTER: Jambunathan K
PROVIDER: S-EPMC3500622 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Jambunathan Kalyani K Watson Douglas S DS Endsley Aaron N AN Kodukula Krishna K Galande Amit K AK
FEBS letters 20120627 16
Post-proline cleaving peptidases are promising therapeutic targets for neurodegenerative diseases, psychiatric conditions, metabolic disorders, and many cancers. Prolyl oligopeptidase (POP; E.C. 3.4.21.26) and fibroblast activation protein α (FAP; E.C. 3.4.24.B28) are two post-proline cleaving endopeptidases with very similar substrate specificities. Both enzymes are implicated in numerous human diseases, but their study is impeded by the lack of specific substrate probes. We interrogated a comb ...[more]