Ontology highlight
ABSTRACT:
SUBMITTER: Peng Y
PROVIDER: S-EPMC4599255 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Peng Yang Y Dong Wen W Lin Tian-Xin TX Zhong Guang-Zheng GZ Liao Bei B Wang Bo B Gu Peng P Huang Li L Xie Yun Y Lu Fu-Ding FD Chen Xu X Xie Wei-Bin WB He Wang W Wu Shao-Xu SX Huang Jian J
Oncotarget 20150601 18
MicroRNA-155 (miR-155) is dysregulated in human cancers. In this study, we reported that miR-155 was over-expressed in bladder cancer tissues. We found that miR-155 promoted cell proliferation in vitro and tumorigenesis in vivo. MiR-155 directly reduced the expression of the tumor suppressor DMTF1. The expression of DMTF1 was decreased in bladder cancer tissues. Similar to the restoring miR-155 expression, knockdown of DMTF1 promoted cell growth and cell cycle progression, whereas DMTF1 over-exp ...[more]