Ontology highlight
ABSTRACT:
SUBMITTER: Ummat A
PROVIDER: S-EPMC3502009 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Ummat Ajay A Rechkoblit Olga O Jain Rinku R Roy Choudhury Jayati J Johnson Robert E RE Silverstein Timothy D TD Buku Angeliki A Lone Samer S Prakash Louise L Prakash Satya S Aggarwal Aneel K AK
Nature structural & molecular biology 20120506 6
A major clinical problem in the use of cisplatin to treat cancers is tumor resistance. DNA polymerase η (Pol-η) is a crucial polymerase that allows cancer cells to cope with the cisplatin-DNA adducts that are formed during chemotherapy. We present here a structure of human Pol-η inserting deoxycytidine triphosphate (dCTP) opposite a cisplatin intrastrand cross-link (PtGpG). We show that the specificity of human Pol-η for PtGpG derives from an active site that is open to permit Watson-Crick geome ...[more]