Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Munoz A
PROVIDER: S-EPMC3502233 | biostudies-literature | 2012 Nov-Dec
REPOSITORIES: biostudies-literature
González-Muñoz Andrea A Bokma Evert E O'Shea Desmond D Minton Kevin K Strain Martin M Vousden Katherine K Rossant Christine C Jermutus Lutz L Minter Ralph R
mAbs 20120827 6
Antibodies are a unique class of proteins with the ability to adapt their binding sites for high affinity and high specificity to a multitude of antigens. Many analyses have been performed on antibody sequences and structures to elucidate which amino acids have a predominant role in antibody interactions with antigens. These studies have generally not distinguished between amino acids selected for broad antigen specificity in the primary immune response and those selected for high affinity in th ...[more]