Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt AC
PROVIDER: S-EPMC3503243 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Schmidt Alexander C AC Schaap-Nutt Anne A Bartlett Emmalene J EJ Schomacker Henrick H Boonyaratanakornkit Jim J Karron Ruth A RA Collins Peter L PL
Expert review of respiratory medicine 20110801 4
In children under 5 years of age, human parainfluenza viruses (HPIVs) as a group are the second most common etiology of acute respiratory illness leading to hospitalization, surpassed only by respiratory syncytial virus but ahead of influenza viruses. Using reverse genetics systems for HPIV serotypes 1, 2 and 3 (HPIV1, 2 and 3), several live-attenuated HPIVs have been generated and evaluated as intranasal vaccines in adults and in children. Two vaccines against HPIV3 were found to be well tolera ...[more]