Triptolide directly inhibits dCTP pyrophosphatase.
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ABSTRACT:
SUBMITTER: Corson TW
PROVIDER: S-EPMC3503517 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Triptolide directly inhibits dCTP pyrophosphatase.
Corson Timothy W TW Cavga Hüseyin H Aberle Nicholas N Crews Craig M CM
Chembiochem : a European journal of chemical biology 20110610 11
Triptolide is a potent natural product, with documented antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and antipolycystic kidney disease effects. Despite a wealth of knowledge about the biology of this compound, direct intracellular target proteins have remained elusive. We synthesized a biotinylated photoaffinity derivative of triptolide, and used it to identify dCTP pyrophosphatase 1 (DCTPP1) as a triptolide-interacting protein. Free triptolide interacts directly with ...[more]
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