Ontology highlight
ABSTRACT:
SUBMITTER: Spitz AZ
PROVIDER: S-EPMC7892824 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Spitz Adam Z AZ Zacharioudakis Emmanouil E Reyna Denis E DE Garner Thomas P TP Gavathiotis Evripidis E
Nature communications 20210218 1
The BCL-2 family protein BAX has essential activity in mitochondrial regulation of cell death. While BAX activity ensures tissue homeostasis, when dysregulated it contributes to aberrant cell death in several diseases. During cellular stress BAX is transformed from an inactive cytosolic conformation to a toxic mitochondrial oligomer. Although the BAX transformation process is not well understood, drugs that interfere with this process are useful research tools and potential therapeutics. Here, w ...[more]