Ontology highlight
ABSTRACT:
SUBMITTER: Carter TC
PROVIDER: S-EPMC3503531 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Carter Tonia C TC Molloy Anne M AM Pangilinan Faith F Troendle James F JF Kirke Peadar N PN Conley Mary R MR Orr David J A DJ Earley Michael M McKiernan Eamon E Lynn Ena C EC Doyle Anne A Scott John M JM Brody Lawrence C LC Mills James L JL
Birth defects research. Part A, Clinical and molecular teratology 20100201 2
<h4>Background</h4>Suggestive, but not conclusive, studies implicate many genetic variants in oral cleft etiology. We used a large, ethnically homogenous study population to test whether reported associations between nonsyndromic oral clefts and 12 genes (CLPTM1, CRISPLD2, FGFR2, GABRB3, GLI2, IRF6, PTCH1, RARA, RYK, SATB2, SUMO1, TGFA) could be confirmed.<h4>Methods</h4>Thirty-one single nucleotide polymorphisms (SNPs) in exons, splice sites, and conserved non-coding regions were studied in 509 ...[more]