Ontology highlight
ABSTRACT:
SUBMITTER: Hobson DJ
PROVIDER: S-EPMC3504299 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Molecular cell 20121004 3
Antisense noncoding transcripts, genes-within-genes, and convergent gene pairs are prevalent among eukaryotes. The existence of such transcription units raises the question of what happens when RNA polymerase II (RNAPII) molecules collide head-to-head. Here we use a combination of biochemical and genetic approaches in yeast to show that polymerases transcribing opposite DNA strands cannot bypass each other. RNAPII stops but does not dissociate upon head-to-head collision in vitro, suggesting tha ...[more]