Ontology highlight
ABSTRACT:
SUBMITTER: Darb-Esfahani S
PROVIDER: S-EPMC3504944 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Darb-Esfahani S S Kronenwett R R von Minckwitz G G Denkert C C Gehrmann M M Rody A A Budczies J J Brase J C JC Mehta M K MK Bojar H H Ataseven B B Karn T T Weiss E E Zahm D M DM Khandan F F Dietel M M Loibl S S
British journal of cancer 20121018 11
<h4>Background</h4>Biomarkers predictive of pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) of breast cancer are urgently needed.<h4>Methods</h4>Using a training/validation approach for detection of predictive biomarkers in HER2-negative breast cancer, pre-therapeutic core biopsies from four independent cohorts were investigated: Gene array data were analysed in fresh frozen samples of two cohorts (n=86 and n=55). Quantitative reverse transcription polymerase chain reacti ...[more]