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Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.

ABSTRACT: The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.

SUBMITTER: Newman AG 

PROVIDER: S-EPMC3505724 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function.

Newman Adam G AG   Vagstad Anna L AL   Belecki Katherine K   Scheerer Jonathan R JR   Townsend Craig A CA  

Chemical communications (Cambridge, England) 20121029 96

The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases. ...[more]

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