Ontology highlight
ABSTRACT:
SUBMITTER: Horstmann N
PROVIDER: S-EPMC3505971 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Horstmann Nicola N Orans Jillian J Valentin-Hansen Poul P Shelburne Samuel A SA Brennan Richard G RG
Nucleic acids research 20120910 21
Hfq is a post-transcriptional regulator that plays a key role in bacterial gene expression by binding AU-rich sequences and A-tracts to facilitate the annealing of sRNAs to target mRNAs and to affect RNA stability. To understand how Hfq from the Gram-positive bacterium Staphylococcus aureus (Sa) binds A-tract RNA, we determined the crystal structure of an Sa Hfq-adenine oligoribonucleotide complex. The structure reveals a bipartite RNA-binding motif on the distal face that is composed of a purin ...[more]