Ontology highlight
ABSTRACT:
SUBMITTER: Belousoff MJ
PROVIDER: S-EPMC5424203 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Belousoff Matthew J MJ Eyal Zohar Z Radjainia Mazdak M Ahmed Tofayel T Bamert Rebecca S RS Matzov Donna D Bashan Anat A Zimmerman Ella E Mishra Satabdi S Cameron David D Elmlund Hans H Peleg Anton Y AY Bhushan Shashi S Lithgow Trevor T Yonath Ada A
mBio 20170509 3
An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of <i>Staphylococcus aureus</i> This high-resolution structural information demonstrated that a single amino acid deletion in ribosomal protein uL3 confers linezolid resistance despite being located 24 Å away from the linezolid binding pocket in the peptidyl-transferase center. The mutation induces a cascade of allosteric st ...[more]